Aging-related phenotypes of 32 inbred mouse strains.
Characterizing inbred strains of mice for aging phenotypes.
Center researchers measured plasma IGF1 levels in aging mice and revealed that IGF1 levels showed an inverse correlation with median lifespan at 6 months.
Center researchers characterizing inbred strains of mice for aging phenotypes at 6,12, and 18 months of age have revealed a genetic influence on electrocardiogram (ECG) time intervals and heart rate in aging mice.
The following tissues are available from a Cross Sectional study of Collaborative Cross (CC) strains.
Protocols are available to the Scientific Community opon request.
The following Tissues are from a cross sectional DO study.
The Translational Core successfully implemented a standardized human-worm-mouse pipeline in which candidate genes identified via the CHARGE consortium are tested in C. elegans by shRNA knockdown for effects on lifespan.
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