NSG-Tg(Hu-IL15) mutant mice combine the features of the severe combined immune deficiency mutation or scid (B and T cell deficiency) and IL2 receptor gamma chain deficiency (NK cell deficiency) with expression of the human IL15 gene on the NOD/ShiLtJ background. Mice homozygous for the three mutations are viable, normal in size and do not display any gross physical or behavioral abnormalities; survival is similar to NSG mice. Hemizygous NSG-Tg(Hu-IL15) mice express a physiological level of human IL15 (7.1 +/- 0.3 pg/ml). Mice irradiated and injected with CD34+ human stems cells (HSC) develop significantly higher levels of functional human CD56+ NK cells in peripheral blood, spleen and bone marrow than NSG controls. This strain may be useful for studying immunotherapies targeting NK cells and NK cell function in tumorigenesis.

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The transgenic NSG-Tg(Hu-IL15) mice express human IL15 and combined with the highly immunodeficient NOD scid gamma (NSG) mouse. Expression of human IL15 enhances the development of human NK cells in immunodeficient mice engrafted with human stem cells. This strain may be useful for studying immunotherapies targeting NK cells and NK cell function in tumorigenesis. CD34+ humanized NSG-IL15 (Stock No. 703089) and PBMC humanized NSG-IL15 (Stock No. 740389) mice can be ordered on our <a href="https://www.jax.org/jax-mice-and-services/preclinical-research-services/humanized-mice/humanized-mice-form">humanized mouse order form</a>.

Homozygous for Prkdc<scid>, Homozygous for Il2rg<tm1Wjl>, Homozygous for Tg(IL15)1Sz

Homozygous for Prkdc<scid>, Hemizygous for Il2rg<tm1Wjl>, Homozygous for Tg(IL15)1Sz